12 May, 2012

Friability Test



 

Tablets are prone to abrasion during transport and handling. Friability test is used to determine the physical strength or tablet breaking force for compressed, uncoated tablets. Friability test enabling us to check for the tablet strength under application of force in different manner.

The friability test is carried out in an instrument called a friabilator. A friability test apparatus should stimulate the conditions that the product will be exposed during the process of production. This test is a method to determine physical strength of uncoated tablets upon exposure to mechanical shock and attrition.

The commonly used friabilator in laboratories is the Roche friabilator.

Remove any loose dust from the tablets and accurately weigh 10 tablets. They are placed in the drum which rotates at 25±1 rpm. Rotate the drum 100 times, and remove the tablets.

The sample fails the test, if any of the 10 tablets cracked, cleaved, or broken is present. If the weight loss is more than 1.0%, the test is repeated for twice and the mean of three tests is calculated. The mean not more than 1.0% is considered acceptable.

Please note that for Effervescent tablets and chewable tablets the friability limits may differ.

If the tablet size or shape becomes irregular adjust the drum so that base forms an angle of about 10 degrees with bench top and the tablets fall freely when drum is rotated.
 

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